Publications

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  • Distribution of the rank of the correct diagnosis of each question by Dolma-based FBPR with k=5.

    Counting Clues: A Lightweight Probabilistic Baseline Can Match an LLM

    arXiv

    Furong Jia, Yuan Pu, Finn Guo, Monica Agrawal

    Read more: Counting Clues: A Lightweight Probabilistic Baseline Can Match an LLM
  • Performance Comparison of MOSAIC With Baselines and Ablation Variants.

    An Agentic AI System for Multi-Framework Communication Coding

    arXiv

    Bohao Yang, Rui Yang, Joshua M. Biro, Haoyuan Wang, Jessica L. Handley, Brianna Richardson, Sophia Bessias, Nicoleta Economou-Zavlanos, Armando D. Bedoya, Monica Agrawal, Michael M. Zavlanos, Anand Chowdhury, Raj M. Ratwani, Kai Sun, Kathryn I. Pollak, Michael J. Pencina, Chuan Hong

    Read more: An Agentic AI System for Multi-Framework Communication Coding
  • ICD-9 depression notes form a tight cluster; ICD-10 depression notes shows a broader semantic dispersion, which mimics the wider distribution.

    Interpreting Dataset Shift in Clinical Notes

    Machine Learning for Health

    Shariar Vaez-Ghaemi, Furong Jia, Monica Agrawal

    Read more: Interpreting Dataset Shift in Clinical Notes
  • Model Test Performance on the Duke Health System dataset when training on some proportion p of the training reports (averaged across 10 random seeds). ±Standard deviation is shaded.

    Context-Aware Filtering of Unstructured Radiology Reports by Anatomical Region

    Machine Learning for Health

    Zakk Heile, Pranav Manjunath, Brian Lerner, Samuel Berchuck, Monica Agrawal, Timothy W DUNN

    Read more: Context-Aware Filtering of Unstructured Radiology Reports by Anatomical Region
  • Mixed data pattern caused by temporal shift due to COVID-19 pandemic. We only know when the pandemic (transition) starts, but don’t know the transition status of each encounter.

    TRACER: Transfer Learning based Real-time Adaptation for Clinical Evolving Risk

    arXiv

    Mengying Yan, Ziye Tian, Siqi Li, Nan Liu, Benjamin A. Goldstein, Molei Liu, Chuan Hong

    Read more: TRACER: Transfer Learning based Real-time Adaptation for Clinical Evolving Risk
  • Example of the impact of random sampling on the representation of patient subgroups.

    Unsupervised Coverage Sampling to Enhance Clinical Chart Review Coverage for Computable Phenotype Development: Simulation and Empirical Study

    JMIR Medical Informatics

    Zigui Wang; Jillian H Hurst; Chuan Hong; Benjamin Alan Goldstein

    Read more: Unsupervised Coverage Sampling to Enhance Clinical Chart Review Coverage for Computable Phenotype Development: Simulation and Empirical Study
  • Flowchart of cohort derivation.

    Calcitonin Gene-Related Peptide (CGRP) Inhibitor Use Is Associated With Increased Cardiovascular Event Risk in Patients with Migraine: A Nationwide Study

    Circulation

    Jay Lusk, MD, MBA, Lauren Wilson, PhD, Carlene Moore, PhD, Stephanie Yarnell, MD, PhD, MBA, Cheryl Kalapura, BS, Aparna Choudhury, BS, Matthew Schrag, MD, PhD, Sven Poli, MD, MSc, Fan Li, PhD, and Brian Mac Grory, MB BCH, BCH

    Read more: Calcitonin Gene-Related Peptide (CGRP) Inhibitor Use Is Associated With Increased Cardiovascular Event Risk in Patients with Migraine: A Nationwide Study
  • Unadjusted event-free survival for patients prescribed GL.P-1RA versus phentermine-topiramate and GLP-1RA vs bupropion-naltrexone respectively.

    Glucagon-Like Peptide-1 Receptor Agonist Use Is Associated With Lower Risk Of Cardiovascular Event Recurrence Compared With Use Of Bupropion-Naltrexone or Phentermine-Topiramate: A Nationwide Target Trial Emulation Study

    Circulation

    Wenxin Guo, MS, Maidou Wang, N/A, Jiwon Shin, MS, Fan Li, PhD, Emily Obrien, MS, PhD, LaShaunta Glover, MS, PhD, Kristina Bortfeld, MD, Shannon Aymes, MD, MPH, Michael Porter, DO, Brian Mac Grory, MB BCH, BCH, and Jay Lusk, MD, MBA

    Read more: Glucagon-Like Peptide-1 Receptor Agonist Use Is Associated With Lower Risk Of Cardiovascular Event Recurrence Compared With Use Of Bupropion-Naltrexone or Phentermine-Topiramate: A Nationwide Target Trial Emulation Study
  • Graph of accumulated risk over days

    Abstract 4370283: Real-World Effectiveness of GLP-1 Receptor Agonists on Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction (HFpEF)

    Circulation

    Cheryl Kalapura, BS, Jiwon Shin, MS, Robert Mentz, BS, MD, Stephen Greene, MD, Brian Mac Grory, MB BCh BAO, Fan Li, PhD, Jay Lusk, MD, MBA, and Emily Obrien, MS, PhD

    Read more: Abstract 4370283: Real-World Effectiveness of GLP-1 Receptor Agonists on Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction (HFpEF)
  • Cover of publication

    Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration Available to Purchase

    Cancer Immunology Research

    Andrea L. Ludwig, Zachary P. McKay, Griffin P. Carter, Mark A. Katz, Georgia Howell, Vaibhav Jain, Stephanie Arvai, Dirk P. Dittmer, Darell D. Bigner, David M. Ashley, Madison L. Shoaf, Annick Desjardins, Simon G. Gregory, Michael C. Brown, Matthias Gromeier

    Read more: Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration Available to Purchase
  • Cover of publication

    TIP-30. Molecularly-guided phase 2 umbrella trial for children and young adults with newly-diagnosed high-grade glioma (HGG) including diffuse intrinsic pontine glioma (DIPG): CONNECT TarGeT (Targeted pediatric HGG therapy) trial in progress 

    Neuro-Oncology

    Margot Lazow, Kathleen Schieffer, Diana Thomas, Vera Paulson, Bonnie Cole, Christine Fuller, Santosh Valvi, Nicholas Gottardo, Michael Fisher, Ashley Plant, Ralph Salloum, Erin Crotty, Eugene Hwang, Anirban Das, Uri Tabori, Hamza Gorsi, Susan Chi, Sarah Leary, Patricia Baxter, Cynthia Hawkins, Michael Hubank, Thomas Jacques, David Jones, Felix Sahm, Mark Cowley, David Ziegler, Michael Rodriguez, Jason Dyke, Thomas Robertson, Joshua Palmer, Kelsey Troyer, Anna Harr, Rachid Drissi, Elaine Mardis, Darren Hargrave, Chris Jones, Maryam Fouladi

    Read more: TIP-30. Molecularly-guided phase 2 umbrella trial for children and young adults with newly-diagnosed high-grade glioma (HGG) including diffuse intrinsic pontine glioma (DIPG): CONNECT TarGeT (Targeted pediatric HGG therapy) trial in progress 
  • Cover of publication

    TIP-25. Randomized phase 2 clinical trial of repeated intratumoral and cervical perilymphatic injections (CPLIs) of lerapolturev vs. lomustine in recurrent glioblastoma (rGBM): safety lead-in results

    Neuro-Oncology

    Madison L Shoaf, Matthias Gromeier, Michael C Brown, Evan D Buckley, James E Herndon II, Kristen Batich, Margaret O Johnson, Mustafa Khasraw, Justin T Low, Katherine B Peters, Allan H Friedman, Henry S Friedman, David M Ashley, Darell D Bigner, Annick Desjardins

    Read more: TIP-25. Randomized phase 2 clinical trial of repeated intratumoral and cervical perilymphatic injections (CPLIs) of lerapolturev vs. lomustine in recurrent glioblastoma (rGBM): safety lead-in results