John Hickey
Co-Associate Director for AI, Assistant Professor
Department: Biomedical Engineering
Home School: Pratt School of Engineering
Email Address: john.hickey@duke.edu
Phone Number: 385-204-8331
Physical Address:
P.O. Box 90281, Durham, NC 27708
Research Overview:
We are interested in developing a computational toolbox (multiscale modeling, bioinformatics, machine learning) to understand how cells organize into multicellular structures, learn what goes awry when these rules are broken, and developing new diagnostic and therapeutic targets.
Publications:
- Preliminary results of first-line botensilimab (BOT) and balstilimab (BAL) optimization in microsatellite stable colorectal cancer (MSS CRC) without liver, bone, or brain metastasis (BBOpCo) Free
- CD39+CD49a+CD103+ cytotoxic tissue-resident natural killer cells infiltrate and control solid epithelial tumor growth in mice
- Foundation cell segmentation models performance on live microscopy and spatial-omics data
- Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors
- Prophylactic inhibition of LATS1/2 before high-dose irradiation promotes the regeneration of the damaged intestinal epithelium