Cancer

Explicitly simulating the transport of circulating tumor cells (CTCs) across anatomical scales with submicron precision—necessary for capturing ligand-receptor interactions between CTCs and endothelial walls—remains infeasible even on modern supercomputers. In this work, we extend the hybrid CPU-GPU adaptive physics refinement (APR) method to couple a moving finely resolved region capturing adhesive dynamics between a cancer…

Parallel agent-based models of the adaptive immune response can efficiently recapitulate emerging spatiotemporal properties of T-cell motility during clonal selection across multiple length and time scales. Here, we present a distributed, three-dimensional (3D) computational model of T-cell priming, and associated parallel data structures and algorithms that enable fully deterministic cell simulations at scale. We demonstrate…