Andreas Seas
PhD: Biomedical Engineering (in progress), Duke University Advisor: Cameron McIntyre Areas of clinical application: Lab site
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Three-dimensional bioprinting of aneurysm-bearing tissue structure for endovascular deployment of embolization coils
Various types of embolization devices have been developed for the treatment of cerebral aneurysms. However, it is challenging to properly evaluate device performance and train medical personnel for device deployment without the aid of functionally relevant models. Current in vitro aneurysm models suffer from a lack of key functional and morphological features of brain vasculature that limit…
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Balloon-Mounted Stents for Treatment of Refractory Flow Diverting Device Wall Malapposition
As indications for flow diversion (FD) have expanded, new challenges in deployment of flow diverting devices (FDDs) have been encountered. We present 4 cases with aneurysms in which deployment of FDDs were complicated by device malapposition and compromised opening in regions of parent vessel stenosis. In all 4 cases, a balloon-mounted stent was ultimately deployed…
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Impact of diversity of morphological characteristics and Reynolds number on local hemodynamics in basilar aneurysms
Morphological and hemodynamic parameters have been suggested to affect the rupture of cerebral aneurysms, but detailed mechanisms of rupture are poorly understood. The purpose of our study is to determine criteria for predicting the risk of aneurysm rupture, which is critical for improved patient management. Existing aneurysm hemodynamics studies generally evaluate limited geometries or Reynolds…
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Hemodynamic and morphological characteristics of a growing cerebral aneurysm
The growth of cerebral aneurysms is linked to local hemodynamic conditions, but the driving mechanisms of the growth are poorly understood. The goal of this study was to examine the association between intraaneurysmal hemodynamic features and areas of aneurysm growth, to present the key hemodynamic parameters essential for an accurate prediction of the growth, and…
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The role of extended reality for planning coronary artery bypass graft surgery
Immersive visual displays are becoming more common in the diagnostic imaging and pre-procedural planning of complex cardiology revascularization surgeries. One such procedure is coronary artery bypass grafting (CABG) surgery, which is a gold standard treat-ment for patients with advanced coronary heart disease. Treatment planning of the CABG surgery can be aided by extended reality (XR)…
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Harvis: an interactive virtual reality tool for hemodynamic modification and simulation
Cardiovascular disease (CVD) affects more than 90 million adults in the United States. In recent years, computational hemodynamic models have helped improve our understanding of CVD progression; however, such research workflows can be challenging and unintuitive to operate. We thus developed Harvis, a software platform with a flexible GUI for performing vascular simulations and a VR-capable interface…
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HarVI: Real-Time Intervention Planning for Coronary Artery Disease Using Machine Learning
Virtual planning tools that provide intuitive user interaction and immediate hemodynamic feedback are crucial for cardiologists to effectively treat coronary artery disease. Current FDA-approved tools for coronary intervention planning require days of preliminary processing and rely on conventional 2D displays for hemodynamic evaluation. Immersion offered by extended reality (XR) has been found to benefit intervention…
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