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Human-Centered Design of a Virtual Reality Intervention to Promote Early Mobility in a Cardiothoracic ICU
Creative solutions are needed to enhance mobility activities in the ICU to combat the sequela of prolonged bed rest. Virtual reality has gained favor for use in outpatient areas, yet the user experience of the ICU patient is relatively unknown. This qualitative study aimed to explore the patient experience of ICU mobility as it relates…
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Deep brain stimulation for depression informed by intracranial recordings
The success of deep brain stimulation (DBS) for treating Parkinson’s disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networksregulating mood, especially on an individual basis. We report results from the first subject treated with…
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Holographic visualization for stereotactic neurosurgery research
Invasive brain neuromodulation therapies are continuously evolving to address a range of neurologic and psychiatric disorders [1]. These clinical efforts rely on the strategic placement of depth electrodes in the brain to interface with the neural circuitry. However, defining the target position and trajectory in the brain for an electrode is an inherently complex 3D problem that requires the integration…
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Augmented reality-based contextual guidance through surgical tool tracking in neurosurgery
External ventricular drain (EVD) is a common, yet challenging neurosurgical procedure of placing a catheter into the brain ventricular system that requires prolonged training for surgeons to improve the catheter placement accuracy. In this article, we introduce NeuroLens, an Augmented Reality (AR) system that provides neurosurgeons with guidance that aids them in completing an EVD…
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Accuracy of routine external ventricular drain placement following a mixed reality–guided twist-drill craniostomy
The traditional freehand placement of an external ventricular drain (EVD) relies on empirical craniometric landmarks to guide the craniostomy and subsequent passage of the EVD catheter. The diameter and trajectory of the craniostomy physically limit the possible trajectories that can be achieved during the passage of the catheter. In this study, the authors implemented a…
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Center Members Win Award at ICCS25
Congratulations to Center director Amanda Randles and members Aristotle Martin and William Ladd for winning Best Main Track Paper Award at the International Conference on Computational Science (ICCS25)!
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Adaptive Physics Refinement for Anatomic Adhesive Dynamics Simulations
Explicitly simulating the transport of circulating tumor cells (CTCs) across anatomical scales with submicron precision—necessary for capturing ligand-receptor interactions between CTCs and endothelial walls—remains infeasible even on modern supercomputers. In this work, we extend the hybrid CPU-GPU adaptive physics refinement (APR) method to couple a moving finely resolved region capturing adhesive dynamics between a cancer…
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Microfluidic Digital Twin for Enhanced Single-Cell Analysis
Advancing single-cell analysis requires tools that not only enable precise experimental measurements but also offer predictive capabilities to guide device optimization and expand experimental possibilities. This study addresses this need by developing a digital twin framework for mechano-node-pore sensing (mechano-NPS), a high-throughput microfluidic platform for single-cell analysis. By creating a virtual replica that integrates models…
