High-throughput adaptive physics refinement for tissue-scale adhesive dynamics
Explicitly resolving ligand–receptor interactions of circulating tumor cells (CTCs) across anatomically realistic vasculature remains computationally prohibitive at the submicrometer fidelity required for adhesive dynamics. In this work, we extend our previously introduced hybrid CPU–GPU adaptive physics refinement (APR) and single-window adaptive physics refinement adhesive dynamics (APR-AD) methods (Martin et al., 2025) into a scalable, high-throughput…
