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Development of a Pipeline for Transitioning Wearable and Non-Wearable Data to a Centralized Storage, Analysis and Downstream Applied Research Platform
The Luck Lab developed an integrated data framework that links youth athletes’ reported activity and exposure with wearable head-impact kinematics to improve the ability to find, track, and treat mild traumatic brain injury.
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Center Members Win Award at ICCS25
Congratulations to Center director Amanda Randles and members Aristotle Martin and William Ladd for winning Best Main Track Paper Award at the International Conference on Computational Science (ICCS25)!
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Adaptive Physics Refinement for Anatomic Adhesive Dynamics Simulations
Explicitly simulating the transport of circulating tumor cells (CTCs) across anatomical scales with submicron precision—necessary for capturing ligand-receptor interactions between CTCs and endothelial walls—remains infeasible even on modern supercomputers. In this work, we extend the hybrid CPU-GPU adaptive physics refinement (APR) method to couple a moving finely resolved region capturing adhesive dynamics between a cancer…
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Investigating the Role of Area Deprivation Index in Observed Differences in CT-Based Body Composition by Race
Differences in CT-based body composition (BC) have been observed by race. We sought to investigate whether indices reporting census block group-level disadvantage, area deprivation index (ADI) and social vulnerability index (SVI), age, sex, and/or clinical factors could explain race-based differences in body composition. Methods The first abdominal CT exams for patients in Durham County at…
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BraTS orchestrator: Democratizing and Disseminating state-of-the-art brain tumor image analysis
The Brain Tumor Segmentation (BraTS) cluster of challenges has significantly advanced brain tumor image analysis by providing large, curated datasets and addressing clinically relevant tasks. However, despite its success and popularity, algorithms and models developed through BraTS have seen limited adoption in both scientific and clinical communities. To accelerate their dissemination, we introduce BraTS orchestrator,…
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Medical Insights, Now Available on Your Wrist
Jessilyn Dunn gathers biometric data from smartwatches to study and predict health changes. Read the article
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Activity-driven chromatin organization during interphase: Compaction, segregation, and entanglement suppression
In mammalian cells, the cohesin protein complex is believed to translocate along chromatin during interphase to form dynamic loops through a process called active loop extrusion. Chromosome conformation capture and imaging experiments have suggested that chromatin adopts a compact structure with limited interpenetration between chromosomes and between chromosomal sections. We developed a theory demonstrating that…
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Theory of chromatin organization maintained by active loop extrusion
The active loop extrusion hypothesis proposes that chromatin threads through the cohesin protein complex into progressively larger loops until reaching specific boundary elements. We build upon this hypothesis and develop an analytical theory for active loop extrusion which predicts that loop formation probability is a nonmonotonic function of loop length and describes chromatin contact probabilities….
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