2022

This paper develops a stochastic model for the spatially-dependent material parameters parameterizing anisotropic strain energy density functions. The construction is cast within the framework of information theory, which is invoked to derive a least-informative model while ensuring consistency with theoretical requirements in finite elasticity. Specifically, almost sure polyconvexity and uniform growth conditions are enforced through…

Coronary artery disease (CAD) is highly prevalent and associated with adverse events. Challenges have emerged in the treatment of intermediate coronary artery stenoses. These lesions are often interrogated with fractional flow reserve (FFR) testing to determine if a stenosis is likely to be causative for ischemia in a cardiac territory. This invasive test requires insertion…

Personalized hemodynamic models can accurately compute fractional flow reserve (FFR) from coronary angiograms and clinical measurements (FFRbaseline), but obtaining patient-specific data could be challenging and sometimes not feasible. Understanding which measurements need to be patient-tuned vs. patient-generalized would inform models with minimal inputs that could expedite data collection and simulation pipelines. Our aims were to…