2025

Surgical resection of malignant solid tumors is critically dependent on the surgeon’s ability to accurately identify pathological tissue and remove the tumor while preserving surrounding healthy structures. However, building an intraoperative 3D tumor model for subsequent removal faces major challenges due to the lack of high-fidelity tumor reconstruction, difficulties in developing generalized tissue models to…

Combining data from diverse sources including randomized controlled trials (RCTs) and observational datasets holds the potential to increase sample size, improve external validity, and gain a well-rounded view of the question under study. However, the practical implementation of integrating different data sources can be complicated, particularly when considering data collected across sites and institutions. In…

METHODS Patients who underwent MViV with balloon-expandable valves at Mayo Clinic Rochester between 2014 and 2023 were retrospectively analyzed. THV expansion (inflow, waist, outtlow) was measured from procedural fluoroscopy and indexed to nominal size, with zero indicating expansion to nominal dimensions. Median index values were used as subgroup cutoffs to compare incidence of the primary…

Metacontrol states involve adapting cognitive control to contextual demands—being more flexible in frequent task-switching environments or more stable in those with infrequent switching. While these metacontrol states can be engaged proactively in anticipation or reactively in response to specific contexts, how these two metacontrol modes interact remains unclear. To address this question, we recorded EEG…

Postoperative delirium, a common complication in geriatric surgery patients, increases dementia1risk and is linked to excessive postoperative inflammation.2 The autonomic nervous system regulates inflammation via the brain–heart–immune axis.3 We hypothesize that a well-functioning brain–heart–immune axis protects against postoperative delirium by preventing excessive postoperative inflammation. In other disease states, enhanced brain–heart–immune axis function via vagus nerve stimulation reduces inflammation and symptom burden.4 Notably,…

Background: The effect of psychological distress on general geriatric surgery outcomes remains unexplored despite recommendations for routine, preoperative distress screening. We aimed to assess preoperative distress measures in a general geriatric surgery cohort, and evaluate associations with postoperative outcomes, including delirium, pain, and length of stay. Methods: This secondary analysis of 132 volunteers in a single-center, prospective…