2026

Atypical Teratoid Rhabdoid Tumors (ATRT) are rare and aggressive pediatric brain tumors, and lack of consensus exists regarding optimal therapy. Some physicians recommend maintenance intrathecal chemotherapy, extrapolating from the salvage setting where it has been reported to promote remission. However, the risks of this therapy may be underappreciated. Here we present a case of a…

BACKGROUND: Brain metastases carry poor prognosis, and accurate survival prediction is critical for treatment planning. Radiomics offers a means of extracting high-dimensional imaging biomarkers, but its prognostic utility in brain metastasis remains unclear. PURPOSE: To evaluate whether MRI-derived radiomic features can improve survival prediction in patients with brain metastases. MATERIALS AND METHODS: This retrospective study developed a T1…

Background Excessive daytime sleepiness may reflect increased vulnerability to postoperative neurocognitive disorders given its association with neurodegenerative disease, cognitive decline, and dementia. However, the role of excessive daytime sleepiness in postoperative neurocognitive disorders is unknown. Here, we investigated whether preoperative moderate–severe excessive daytime sleepiness is associated with postoperative neurocognitive disorder severity. Methods This prospective observational…

The National Academy of Engineering (NAE)’s Engineer of 2020 call for educational reform emphasized the need for engineering schools to raise suitable leaders to respond to the rapid evolution of technology. Five years after the reforms were supposed to be implemented in 2020, we argue that leadership education is still not structurally scaffolded into engineering…

Background Recurrent acute otitis media (rAOM) affects 10-15% of children in the United States and is a leading cause of healthcare utilization and antibiotic prescriptions, accounting for over $1.3 billion in healthcare costs annually. Current treatments for rAOM include expectant management and tympanostomy tube (TT) placement; however, recent studies have suggested limited benefits of TT…

Background: The current landscape of emergency care (EC) is marked by high demand, leading to issues such as emergency department boarding, overcrowding, and subsequent delays that impact the quality and safety of patient care. Integrating data science into EC can enhance decision-making with predictive, preventative, personalized, and participatory approaches. However, gaps in adherence to fairness, accountability,…

Background: Recurrent spontaneous abortion (RSA) is a multifactorial reproductive disorder affecting 1%–2% of couples globally, with up to 50% of cases remaining idiopathic. Trefoil factor 3 (TFF3), a mucosal protective peptide expressed in the endometrium during the implantation window, supports epithelial repair and mucus production essential for successful pregnancy. Genetic variants in TFF3 have been…