2018

Cover of Computer Methods in Applied Mechanics and Engineering

A random field model for anisotropic strain energy functions and its application for uncertainty quantification in vascular mechanics

This paper deals with the construction of random field models for spatially-dependent anisotropic strain energy functions indexed by complex geometries. The approach relies on information theory and the principle of maximum entropy, which are invoked in order to construct the family of first-order marginal probability distributions in accordance with fundamental constraints such as polyconvexity, coerciveness…

Three bar graphs showing the relationship between lesion characteristics and resting pressure gradient, IFR, and DSVR.

Computational Fluid Modeling to Understand the Role of Anatomy in Bifurcation Lesion Disease

Treatment of bifurcation lesion disease is complex with limited studies that describe the influence of lesion anatomy on clinical outcomes. We hypothesize that computational simulations can be used to understand the interplay between morphological characteristics of lesion and clinical diagnostic metrics. Methods we used include: Geometric modifications along the bifurcation in a patient-derived left coronary…

Cover of AIChE Journal

Impact of diversity of morphological characteristics and Reynolds number on local hemodynamics in basilar aneurysms

Morphological and hemodynamic parameters have been suggested to affect the rupture of cerebral aneurysms, but detailed mechanisms of rupture are poorly understood. The purpose of our study is to determine criteria for predicting the risk of aneurysm rupture, which is critical for improved patient management. Existing aneurysm hemodynamics studies generally evaluate limited geometries or Reynolds…